Post by livelonger on Sept 29, 2016 15:45:58 GMT -5
New research by scientists at Beth Israel Deaconess Medical Center and Harvard Medical School, and sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases, suggests that consuming too much dietary sugar could set off a process in the body that leads to prediabetes and type 2 diabetes.
Study author Dr. Mark Herman, now an assistant professor in the Division of Endocrinology, Metabolism and Nutrition at Duke University School of Medicine, told CBS News that the study, conducted in mice and human liver samples, revealed a specific mechanism that shows that consuming large amounts of sugar, especially fructose, appears to be a trigger. Fructose is commonly used as a sweetener but it also occurs naturally in fruits, vegetables and honey.
...
excessive sugar in the liver appears to activate a molecular factor known as carbohydrate-responsive element-binding protein – ChREBP. Activating this factor causes the liver to keep making glucose, contributing to increased blood glucose levels despite insulin signals telling it to stop.
“We found that no matter how much insulin the pancreas made, it couldn’t override the processes started by this protein, ChREBP,” he explained. Ultimately it caused blood sugar and insulin levels to increase, which over time can lead to insulin resistance elsewhere in the body.
...
80 percent of type 2 diabetes cases are linked with obesity.
...
She now limits both fruit and fruit juice. For example, no grapes (1 cup has about 15 grams of sugar), only higher fiber berries (1 cup of strawberries has about 7 grams of sugar). She’s also eating more protein and has done away with white, starchy carbohydrates in favor of whole grain options. She makes sure she eats proteins with carbohydrates, which helps keep her blood sugar steady. And no more big desserts, just a few bites on occasion.
Adding exercise to her weekly routine is also helping regulate Yang’s blood sugar, and her doctor prescribed medication, too. But she says she has to be careful about her weight – when it goes up even a few pounds, so do her A1C numbers.
By MARY BROPHY MARCUS CBS NEWS September 29, 2016, 3:03 PM
Can eating too much sugar cause type 2 diabetes?
Study author Dr. Mark Herman, now an assistant professor in the Division of Endocrinology, Metabolism and Nutrition at Duke University School of Medicine, told CBS News that the study, conducted in mice and human liver samples, revealed a specific mechanism that shows that consuming large amounts of sugar, especially fructose, appears to be a trigger. Fructose is commonly used as a sweetener but it also occurs naturally in fruits, vegetables and honey.
...
excessive sugar in the liver appears to activate a molecular factor known as carbohydrate-responsive element-binding protein – ChREBP. Activating this factor causes the liver to keep making glucose, contributing to increased blood glucose levels despite insulin signals telling it to stop.
“We found that no matter how much insulin the pancreas made, it couldn’t override the processes started by this protein, ChREBP,” he explained. Ultimately it caused blood sugar and insulin levels to increase, which over time can lead to insulin resistance elsewhere in the body.
...
80 percent of type 2 diabetes cases are linked with obesity.
...
She now limits both fruit and fruit juice. For example, no grapes (1 cup has about 15 grams of sugar), only higher fiber berries (1 cup of strawberries has about 7 grams of sugar). She’s also eating more protein and has done away with white, starchy carbohydrates in favor of whole grain options. She makes sure she eats proteins with carbohydrates, which helps keep her blood sugar steady. And no more big desserts, just a few bites on occasion.
Adding exercise to her weekly routine is also helping regulate Yang’s blood sugar, and her doctor prescribed medication, too. But she says she has to be careful about her weight – when it goes up even a few pounds, so do her A1C numbers.
By MARY BROPHY MARCUS CBS NEWS September 29, 2016, 3:03 PM
Can eating too much sugar cause type 2 diabetes?
